Publications

Automatic quality evaluation of whole slide images for the practical use of whole slide imaging scanner

Hossain Md Shakhawat, Tomoya Nakamura, Fumikazu Kimura, Yukako Yagi, Masahiro Yamaguchi

ITE Transactions On Media Technology And Applications , Vol. 8 (4) , pp. 252-268

A whole slide imaging (WSI) scanner scans pathological-specimens to produce digital images for monitor-based diagnosis and analysis. However, the image quality is sometimes insufficient due to focus-error or noise, in which case the slide needs to be rescanned. In …

Automatic quantification of HER2 gene amplification in invasive breast cancer from chromogenic in situ hybridization whole slide images

Md Shakhawat Hossain, Matthew G Hanna, Naohiro Uraoka, Tomoya Nakamura, Marcia Edelweiss, Edi Brogi, Meera R Hameed, Masahiro Yamaguchi, Dara S Ross, Yukako Yagi

Journal of Medical Imaging , Vol. 6 (4)

Human epidermal growth factor receptor 2 (HER2), a transmembrane tyrosine kinase receptor encoded by the ERBB2 gene on chromosome 17q12, is a predictive and prognostic biomarker in invasive breast cancer (BC). Approximately 20% of BC are HER2-positive as a result of ERBB2 gene …